Clinical Chemistry

For the Leiden Longevity Study, long-lived siblings of European descent were recruited together with their offspring and the partners of the offspring between 2002 and 2006. Families were recruited if at least two long-lived siblings were alive and fulfilled the age criterion of 89 years or older for males and 91 years or older for females, representing less than 0.5% of the Dutch population in 2001 (Schoenmaker et al 2006, doi: 10.1038/sj.ejhg.5201508; Westendorp et al 2009, doi: 10.1111/j.1532-5415.2009.02381.x). In total 944 long-lived siblings were included with a mean age of 94 years (range 89-104), 1671 offspring (61 years, 34-81) and 744 partners (60 years, 30-79) as population based controls. It is family based study consists of 1671 offspring of 421 nonagenarians sibling pairs of Dutch descent, and their 744 partners. The dataset of the LLS IOP1 Partner Offspring consists of the 1671 offspring of nonagenarian siblings and their 744 partners from 421 families of whom we have physical measurements, biosamples, biomarkers, and questionnaire data. We followed this group of 2,415 middle-aged participants for their vital status till 2020, for their morbidity status till 2017.